Record Details

Evaluating human exposure to aflatoxins: A case study on aflatoxinalbumin adduct levels in end stage liver disease patients in India

OAR@ICRISAT

View Archive Info
 
 
Field Value
 
Relation http://oar.icrisat.org/7483/
 
Title Evaluating human exposure to aflatoxins: A case study on aflatoxinalbumin adduct levels in end stage liver disease patients in India
 
Creator Anitha, S
Waliyar, F
Sudini, H
Digumarti, R S
 
Subject Groundnut
 
Description Aflatoxin B1, a secondary metabolite of Aspergillus flavus and A. parasiticus,
is a frequent contaminant of several food crops. The main objective of this
study was to know the effect of post exposure of aflatoxin in humans through
consumption of contaminated foods. The aflatoxin-albumin level of selected
human populations in India were analysed. A total of 673 blood samples were
further analyzed by Indirect competitive Enzyme linked immunosorbent assay
(IC-ELISA) method. The samples were collected along with clinical profile,
demographic and food consumption data from the individuals with different
stages of liver disease. The severity of the liver disease was calculated based
on the “Model for End stage Liver Disesae” (MELD) score. The results
indicated 86 of 673 samples have concentration of aflatoxin-albumin adduct
ranged between 2.5 to 677 pg mg-1 of albumin with mean adduct level 181.9
±5 and SD 1.49 ± 7. At 5% level of significance pb value 0.039 (
 
Date 2013
 
Type Conference or Workshop Item
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://oar.icrisat.org/7483/1/PhytoPath_103_suppl_S2_129_2013.pdf
Anitha, S and Waliyar, F and Sudini, H and Digumarti, R S (2013) Evaluating human exposure to aflatoxins: A case study on aflatoxinalbumin adduct levels in end stage liver disease patients in India. In: 2013 APS-MSA Joint Meeting, 10-14 August 2013, Austin, Texas USA.