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Insecticidal activity of a novel fatty acid amide derivative from Streptomyces species against Helicoverpa armigera

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Relation http://oar.icrisat.org/9391/
http://dx.doi.org/10.1080/14786419.2016.1154055
 
Title Insecticidal activity of a novel fatty acid amide
derivative from Streptomyces species against
Helicoverpa armigera
 
Creator Gopalakrishnan, S
Rajendran, V
Arumugam, S
Sharma, H C
Vadlamudi, S
Bhimineni, R K
Gonzalez, S V
Melø, T M
Simic, N
 
Subject Plant Pathology
Entomology
 
Description Helicoverpa armigera, an important pest causes serious damage
to grain legumes. The main objective of this study was to isolate
and identify the metabolite against H. armigera from a previously
characterised Streptomyces sp. CAI-155. The culture filtrate of CAI-
155 was extracted using Diaion HP-20 and the active fractions were
fractionated on Silica and C18 column chromatography. The C18
active fraction was further fractionated on Silica gel 60 F254 thin layer
chromatography (TLC). The most active fraction (Rf 0.64) purified from
TLC led to the identification of a novel metabolite N-(1-(2,2-dimethyl-
5-undecyl-1,3-dioxolan-4-yl)-2-hydroxyethyl)stearamide by spectral
studies. The purified metabolite showed 70–78% mortality in 2nd
instar H. armigera by diet impregnation assay, detached leaf assay and
greenhouse assay. The LD50 and LD90 values of the purified metabolite
were 627 and 2276 ppm, respectively. Hence, this novel metabolite
can be exploited for pest management in future.
 
Publisher Taylor & Francis
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://oar.icrisat.org/9391/1/NatProdRes_2016.pdf
Gopalakrishnan, S and Rajendran, V and Arumugam, S and Sharma, H C and Vadlamudi, S and Bhimineni, R K and Gonzalez, S V and Melø, T M and Simic, N (2016) Insecticidal activity of a novel fatty acid amide derivative from Streptomyces species against Helicoverpa armigera. Natural Product Research. pp. 1-10. ISSN 1478-6419