Guaiane sesquiterpenes from seaweed Ulva fasciata Delile and their antibacterial properties
CMFRI Repository
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Relation |
http://eprints.cmfri.org.in/10778/
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Title |
Guaiane sesquiterpenes from seaweed Ulva fasciata Delile and their antibacterial properties |
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Creator |
Chakraborty, Kajal
Lipton, A P Paulraj, R Chakraborty, Rekha D |
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Subject |
Bioactive compounds
Biochemistry Seaweed |
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Description |
Two new guaiane sesquiterpene derivatives, guai-2-en-10a-ol (1) and guai-2-en-10a-methanol (2), were chromatographically purified as major constituents of the CHCl3/CH3OH (1:1, v/v) soluble fraction of Ulva fasciata. Acetylation of 2 furnished guai-2-en-10a-methyl methanoate (3) with acetyl group at C11 position. The structures of the compounds were elucidated using one and two-dimensional NMR and mass spectrometric analysis. Compounds 2 and 3 exhibited significant inhibition to the growth of Vibrio parahaemolyticus with minimum inhibitory concentrations of 25 and 35 mg/mL, respectively. The electronegative C10 acetyl group with high polarisability (7.02� 10�24 cm3) in 3 appeared to withdraw electron cloud from substituted cycloheptyl ring and (R)-3-methylcyclohept-1-ene moiety, thus acting as the nucleophilic center of the molecule resulting in high bioactivity. |
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Publisher |
Elsevier
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Date |
2010
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Type |
Article
PeerReviewed |
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Format |
text
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Language |
en
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Identifier |
http://eprints.cmfri.org.in/10778/1/European%20Journal%20of%20Medicinal%20Chemistry_45_2010_Kajal%20Chakraborty.pdf
Chakraborty, Kajal and Lipton, A P and Paulraj, R and Chakraborty, Rekha D (2010) Guaiane sesquiterpenes from seaweed Ulva fasciata Delile and their antibacterial properties. European Journal of Medicinal Chemistry, 45. pp. 2237-2244. |
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