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Toxicity profile of a nutraceutical formulation derived from green mussel Perna viridis.

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Relation http://eprints.cmfri.org.in/10781/
 
Title Toxicity profile of a nutraceutical formulation derived from green mussel Perna viridis.
 
Creator Chakraborty, Kajal
Joseph, Dexy
Chakkalakal, Selsa Jose
 
Subject Bioactive compounds
Biochemistry
 
Description The short-term (acute) and long-term (subchronic) toxicity profile, mean lethal dose 50 (LD50), and no-observed-adverse-effect level (NOAEL) of a nutraceutical formulation developed from green mussel Perna viridis, which showed in vitro and in vivo anti-inflammatory properties, were evaluated in the present study. The formulation was administered to the male and female Wistar rats at graded doses (0.5, 1.0, and 2.5 g/kg body weight) for two weeks of acute toxicity study and 0.5, 1.0, and 2.0 g/kg body weight for 90 days in subchronic toxicity study. The LD50, variations in clinical signs, changes in body weight, body weight, food/water consumption, organ weight (liver, kidney, spleen, and brain), hematology, serum chemistry, and histopathological changes were evaluated. The LD50 of the formulation was 5,000 mg/kg BW. No test article related mortalities as well as change in body weight, and food and water consumption were observed. No toxicity related significant changes were noted in renal/hepatic function, hematological indices, and serum biochemical parameters between the control and treated groups. Histopathological alterations were not observed in the vital organs of rats. The subchronic NOAEL for the formulation in rats is greater than 2000 mg/kg. This study demonstrated that the green mussel formulation is safe to consume without any adverse effects in the body.
 
Publisher Hindawi Publishing Corporation
 
Date 2014
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/10781/1/Toxicity%20profile_BioMed%20Research%20International_Kajal%20Chakraborty_2014.pdf
Chakraborty, Kajal and Joseph, Dexy and Chakkalakal, Selsa Jose (2014) Toxicity profile of a nutraceutical formulation derived from green mussel Perna viridis. BioMed Research International, 2014. pp. 1-14.