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Modification of pattern of excitatory junction currents in the guinea pig vas deferens by the gap junction uncoupler heptanol

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Title Modification of pattern of excitatory junction currents in the guinea pig vas deferens by the gap junction uncoupler heptanol
 
Creator MANCHANDA, R
VENKATESWARLU, K
 
Description Extracellularly recorded excitatory junction currents (EJCs) produced by neurotransmission to the smooth muscle of the vas deferens have a varied phasic composition, They can be positive going (p-EJC), negative going (n-EJC) or biphasic (b-EJC) from one event to the next. The phasicity is believed to depend upon the syncytial properties of the smooth muscle cells, We have investigated the effects of 1- heptanol, an intercellular uncoupling agent, on the phasicity of EJCs. In control Krebs solution EJCs with a positive phase (p- and b-EJCs) occurred as a considerable fraction of total EJCs recorded, Following the application of 2 mM heptanol for 2-3 min., the occurrence of p- and b-EJCs decreased markedly while that of n-EJCs increased. The change was reversible and repeatable. Heptanol did not, however, affect the prejunctional nerve action potential. These bioelectric results can be explained in terms of the specific uncoupling of smooth muscle cells by heptanol.
 
Publisher IEEE
 
Date 2011-10-22T02:02:02Z
2011-12-15T09:10:39Z
2011-10-22T02:02:02Z
2011-12-15T09:10:39Z
1997
 
Type Proceedings Paper
 
Identifier PROCEEDINGS OF THE 18TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 18, PTS 1-5,18,1769-1770
0-7803-3812-X
http://dspace.library.iitb.ac.in/xmlui/handle/10054/14790
http://hdl.handle.net/100/1579
 
Source 18th Annual International Conference of IEEE Engineering-in-Medicine-amd-Biology-Society,AMSTERDAM, NETHERLANDS,OCT 31-NOV 03, 1996
 
Language English