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Modeling and simulation of cantilever biosensor (for MI) based on molecular electrostatic interactions

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Title Modeling and simulation of cantilever biosensor (for MI) based on molecular electrostatic interactions
 
Creator RANE, TD
GANDHI, PS
 
Subject biosensor
modeling and simulation
myocardial infarction
 
Description Microcantilever based biosensors are increasingly used for several bio-applications. hi this paper a model based on electrostatic interactions between bio-molecules is proposed to explain the cantilever deflection in biosensor. This modeling, at molecular level, is difficult due to large number of molecules and large simulation times involved. This problem is overcome by evaluating the electrostatic interactions between the groups of molecules rather than the individual molecules. The analysis shows that for sufficiently fine grids (small groups of molecules), the results don't vary much even if the grid is made finer. Simulations carried out verify the analytical results. Simulations carried out also show that the cantilever biosensor deflections match fairly with the experimental data obtained for myoglobin marker for myocardial infarction (MI) published recently. The discrepancies are attributed to surface irregularities which are not considered in the model. It is also observed that the deflection obtained for non-uniform distribution of biomolecules on the cantilever surface (more close to the actual case) doesn't vary much from a uniform distribution. Though the model is validated using results for myoglobin markers used in detection of MI, the modeling and simulation methodology is fairly general and will be valid for other biosensors.
 
Publisher SPIE-INT SOC OPTICAL ENGINEERING
 
Date 2011-10-24T01:34:53Z
2011-12-15T09:11:21Z
2011-10-24T01:34:53Z
2011-12-15T09:11:21Z
2005
 
Type Proceedings Paper
 
Identifier MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS III,5718,255-264
0-8194-5692-6
0277-786X
http://dx.doi.org/10.1117/12.590862
http://dspace.library.iitb.ac.in/xmlui/handle/10054/15296
http://hdl.handle.net/100/2019
 
Source Conference on Microfludics, BioMEMS, and Medical Microsystems III,San Jose, CA,JAN 24-26, 2005
 
Language English