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Dissolved core alginate microspheres as "Smart-Tattoo" glucose sensors

DSpace at IIT Bombay

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Title Dissolved core alginate microspheres as "Smart-Tattoo" glucose sensors
 
Creator CHAUDHARY, A
RAINA, M
MCSHANE, MJ
SRIVASTAVA, R
 
Subject affinity sensor
nanofilm coatings
concanavalin-a
blood-glucose
binding
oxidase
encapsulation
microcapsules
performance
biosensors
 
Description The feasibility of multilayer thin film coated dissolved-core alginate-templated microsphere sensors based on fluorescence resonance energy transfer and competitive binding, was explored in simulated interstitial fluid, using glucose as a model analyte. The glucose sensitivity was observed to be 0.89%/mM glucose with a linear response in the range of 0-50mM glucose. The sensor response was observed to be completely reversible in nature with a response time of 120 seconds. The system was further demonstrated to respond similarly using near-infrared dyes (Alexa Fluor-647-labeled dextran as donor and QSY-21-conjugated apo-GOx as acceptor) which exhibited a sensitivity of 0.94%/mM glucose with a linear response in range of 0-50mM glucose, making the sensor more amenable to in vivo use, when implanted in scattering tissue.
 
Publisher IEEE
 
Date 2011-10-25T16:37:22Z
2011-12-15T09:12:01Z
2011-10-25T16:37:22Z
2011-12-15T09:12:01Z
2009
 
Type Proceedings Paper
 
Identifier EMBC: 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20,4098-4101
978-1-4244-3295-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/15769
http://hdl.handle.net/100/2428
 
Source Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society,Minneapolis, MN,SEP 03-06, 2009
 
Language English