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An ultra-sensitive delta R/R measurement system for biochemical sensors using Piezoresistive Micro-Cantilevers

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Title An ultra-sensitive delta R/R measurement system for biochemical sensors using Piezoresistive Micro-Cantilevers
 
Creator NAG, S
KALE, NS
RAO, VR
SHARMA, DK
 
Subject delta r/r measurement
polymeric micro-cantilever
piezoresistor
lock-in amplifier
probe station
deflection sensitivity
myoglobin
 
Description Piezoresistive micro-cantilevers are interesting bio-sensing tool whose base resistance value (R) changes by a few parts per million (Delta R) in deflected conditions. Measuring such a small deviation is always being a challenge due to noise. An advanced and reliable Delta R/R measurement scheme is presented in this paper which can sense resistance changes down to 6 parts per million. The measurement scheme includes the half-bridge connected micro-cantilevers with mismatch compensation, precision op-amp based filters and amplifiers, and a lock-in amplifier based detector. The input actuating sine wave is applied from a function generator and the output dc voltage is displayed on a digital multimeter. The calibration is performed and instrument sensitivity is calculated. An experimental set-up using a probe station is discussed that demonstrates a combined performance of the measurement system and SU8-polysilicon cantilevers. The deflection sensitivity of such polymeric cantilevers is calculated. The system will be highly useful to detect bio-markers such as myoglobin and troponin that are released in blood during or after heart attacks.
 
Publisher IEEE
 
Date 2011-10-25T21:33:06Z
2011-12-15T09:12:09Z
2011-10-25T21:33:06Z
2011-12-15T09:12:09Z
2009
 
Type Proceedings Paper
 
Identifier EMBC: 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20,3794-3797
978-1-4244-3295-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/15826
http://hdl.handle.net/100/2496
 
Source Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society,Minneapolis, MN,SEP 03-06, 2009
 
Language English