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Ferrite-Silica-Insulin nanocomposites (FeSINC) for glucose reduction

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Title Ferrite-Silica-Insulin nanocomposites (FeSINC) for glucose reduction
 
Creator DWIVEDI, N
ARUNAGIRINATHAN, MA
SHARMA, S
BELLARE, J
 
Subject controlled drug-delivery
raman-spectroscopy
systems
carrier
silica
ferrite
insulin
nanocomposite
 
Description Proteins find more stable environment upon encapsulation in a silica host, because of polymeric silica frame that grows around the macromolecule and protects them from denaturation. Silica-insulin nanocomposite (SINC) and ferrite coated SINC (FeSINC) prepared by polyelectrolytic condensation of silica precursor on insulin were studied for their ability to control glucose levels. SINC was prepared by acid- base catalysed polymerization in presence of insulin at room temperature by modified Stober's process. FeSINC nanoparticles were prepared by co-precipitation of both ferric and ferrous salts on the bovine insulin loaded silica nanoparticle. The presence of ferrite coating in FeSINC was identified using VSM and quantified from XRF study. The intermolecular interactions in these nanocomposites were studied by FTIR and Raman spectroscopy. An in vivo study indicated that FeSINC was biologically active in reducing glucose levels as compared to SINC.
 
Publisher CRC PRESS-TAYLOR & FRANCIS GROUP
 
Date 2011-10-25T23:00:12Z
2011-12-15T09:12:12Z
2011-10-25T23:00:12Z
2011-12-15T09:12:12Z
2008
 
Type Proceedings Paper
 
Identifier NSTI NANOTECH 2008, VOL 1, TECHNICAL PROCEEDINGS,770-773
978-1-4200-8503-7
http://dspace.library.iitb.ac.in/xmlui/handle/10054/15840
http://hdl.handle.net/100/2527
 
Source Nanotechnology Conference and Trade Show (Nanotech 2008),Boston, MA,JUN 01-05, 2008
 
Language English