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Prejunctional and postiunctional actions of heptanol and 18 beta-glycyrretinic acid in the rodent vas deferens

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Title Prejunctional and postiunctional actions of heptanol and 18 beta-glycyrretinic acid in the rodent vas deferens
 
Creator RAHMAN, F
MANCHANDA, R
BRAIN, KL
 
Subject heptanol
18 beta-glycyrretinic acid
sympathetic neurotransmission
gap junctions
smooth muscle
smooth-muscle-cells
excitatory junction potentials
guinea-pig
intercellular communication
gap-junctions
glycyrrhetinic acid
rat
arteries
contractions
hyperpolarization
 
Description Heptanol and 18 beta-glycyrrhetinic acid (18 beta GA) block gap junctions, but have other actions on transmitter release that have not been characterised. This study investigates the prejunctional and postjunctional effects of these compounds in guinea pig and mouse vas deferens using intracellular electrophysiological recording and confocal Ca(2+) imaging of sympathetic nerve terminals. In mice, heptanol (2 mM) reversibly decreased the amplitude of purinergic excitatory junction potentials (EJPs: 52 +/- 5%, P
 
Publisher ELSEVIER SCIENCE BV
 
Date 2011-10-12T14:33:34Z
2011-12-15T09:16:04Z
2011-10-12T14:33:34Z
2011-12-15T09:16:04Z
2009
 
Type Review
 
Identifier AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL,148,69-75
1566-0702
http://dx.doi.org/10.1016/j.autneu.2009.03.006
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13802
http://hdl.handle.net/100/2982
 
Language en