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Synthesis of diverse polycyclic compounds via catalytic metathesis

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Title Synthesis of diverse polycyclic compounds via catalytic metathesis
 
Creator KOTHA, S
LAHIRI, K
 
Subject amino acids
polycycles
metathesis
heterocycles
spiro compounds
ring-closing metathesis
amino-acid derivatives
diels-alder reaction
cross-enyne metathesis
cyclic 1-amino-1-carboxylic acids
allylic acetate isomerization
imido alkylidene complexes
olefin-metathesis
claisen rearrangement
key steps
 
Description A variety of olefin-metathesis protocols have been used to prepare spirocyclic compounds, cyclic sulfones, and constrained a-amino acid derivatives. Conceptually, a new approach to a novel cyclophane ring system has been realized via ring-closing metathesis (RCM). Also, tetracyclic compounds related to anthracycline antibiotics have been assembled using Claisen rearrangement and RCM as key steps. Further, a sequential use of the Diels-Alder reaction and ring-opening cross-metathesis delivered highly fuctionalized spiroindane derivatives, and trisubstituted benzene derivatives have been assembled using Grubbs' catalyst. Finally, the enyne and cross-enyne metathesis sequences have been used to prepare several constrained cc-amino acid derivatives. 1 Introduction 2 Application of Ring-Closing Metathesis To Give Spiro-cyclic Compounds 3 Application of Ring-Closing Metathesis To Give Cyclophane Derivatives 4 Application of Ring-Closing Metathesis To Give Cyclic Sulfone Derivatives 5 Application of Ring-Closing Metathesis To Give Cyclic alpha-Amino Acid Derivatives and Modified Peptides 6 Application of Ring-Closing Metathesis to Benzannulation 7 Application of Enyne Metathesis to the Synthesis of Constrained a-Amino Acid and Naphthoxepin Derivatives 8 Application of Cross-Enyne Metathesis to the Synthesis of Highly Functionalized Phenylatanine Derivatives 9 Application of Ring-Opening Cross-Metathesis to Spiro-indanes 10 Synthesis of Trisubstituted Benzene Derivatives Using Grubbs' Catalyst 11 Metathesis of a Novel Enyne System 12 Macroheterocycles via Cross-Enyne and Ring-Closing Metathesis Cascade Reactions 13 Conclusions.
 
Publisher GEORG THIEME VERLAG KG
 
Date 2011-10-12T11:26:40Z
2011-12-15T09:16:05Z
2011-10-12T11:26:40Z
2011-12-15T09:16:05Z
2007
 
Type Review
 
Identifier SYNLETT,(18)2767-2784
0936-5214
http://dx.doi.org/10.1055/s-2007-990954
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13757
http://hdl.handle.net/100/2991
 
Language en