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Targeting ftsz for antibacterial therapy: a promising avenue

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Title Targeting ftsz for antibacterial therapy: a promising avenue
 
Creator KAPOOR, S
PANDA, D
 
Subject antibacterials
bacterial cytokinesis
drug-targets
ftsz
z-ring
bacterial-cell-division
structure-based design
microtubule assembly dynamics
escherichia-coli
protein ftsz
bacillus-subtilis
drug discovery
septal ring
crystal-structure
gtpase activity
 
Description The widespread problem of bacterial resistance towards existing drugs and the paucity of effective drugs for the treatment of bacterial infections have prompted the scientific community to think about novel strategies for discovering new classes of antibacterial drugs. Target-based screening of inhibitory molecules has emerged as an important alternative for the development of potent antibacterials. FtsZ is a prokaryotic cytoskeleton protein, which plays an important role in bacterial cell division. It forms a highly dynamic Z-ring at the centre of the cell and recruits other accessory proteins, which are involved in bacterial cytokinesis. Here, we discuss the assembly dynamics of FtsZ and the key features that place it among the novel antibacterial drug targets. The recent progress in finding the inhibitors of functional properties of FtsZ and its interactions with other proteins, which has been enabled by advanced screening methods and structure-based design, are presented herein. Although there are significant challenges in the development of this new class of antibacterial drugs, nonetheless the therapeutic potential of FtsZ as a drug target is motivating researchers to find lead molecules with enhanced efficacy and reduced toxicity.
 
Publisher INFORMA HEALTHCARE
 
Date 2011-10-12T11:37:54Z
2011-12-15T09:16:06Z
2011-10-12T11:37:54Z
2011-12-15T09:16:06Z
2009
 
Type Review
 
Identifier EXPERT OPINION ON THERAPEUTIC TARGETS,13(9)1037-1051
1472-8222
http://dx.doi.org/10.1517/14728220903173257
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13760
http://hdl.handle.net/100/2994
 
Language en