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Discovery and syntheses of "superbug challengers"-platensimycin and platencin

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Title Discovery and syntheses of "superbug challengers"-platensimycin and platencin
 
Creator PALANICHAMY, K
KALIAPPAN, KP
 
Subject antibiotics
bacterial infection
fatty acids
platencin
platensimycin
diels-alder reactions
fatty-acid synthesis
silyl enol ethers
asymmetric allylic alkylation
formal total-synthesis
alpha,beta-unsaturated carbonyl-compounds
palladium-catalyzed hydrogenolysis
enantioselective total-synthesis
polyvalent iodine compounds
radical-type cyclization
 
Description Bacteria have developed resistance to almost all existing antibiotics known today and this has been a major issue over the last few decades. The search for a new class of antibiotics with a new mode of action to fight these multiply-drug-resistant strains, or "superbugs", allowed a team of scientists at Merck to discover two novel antibiotics, platensimycin and platencin using advanced screening strategies, as inhibitors of bacterial fatty acid biosynthesis, which is essential for the survival of bacteria. Though both these antibiotics are structurally related. they work by slightly different mechanisms and target different enzymes conserved in the bacterial fatty acid biosynthesis. This Focus Review summarizes the synthetic and biological aspects of these natural products and their analogues and congeners.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2011-10-12T11:40:43Z
2011-12-15T09:16:06Z
2011-10-12T11:40:43Z
2011-12-15T09:16:06Z
2010
 
Type Review
 
Identifier CHEMISTRY-AN ASIAN JOURNAL,5(4)668-703
1861-4728
http://dx.doi.org/10.1002/asia.200900423
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13761
http://hdl.handle.net/100/2995
 
Language en