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Diversity-oriented approach to biologically relevant molecular frameworks starting with beta-naphthol and using the claisen rearrangement and olefin metathesis as key steps

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Title Diversity-oriented approach to biologically relevant molecular frameworks starting with beta-naphthol and using the claisen rearrangement and olefin metathesis as key steps
 
Creator KOTHA, S
MANDAL, K
TIWARI, A
MOBIN, SM
 
Subject claisen rearrangement
diversity-oriented synthesis
metathesis
naphthoxepines
spiro compounds
ring-closing metathesis
allylic acetate isomerization
catalyzed enyne metathesis
amino-acid derivatives
diels-alder reaction
silica-gel support
organic-synthesis
grubbs catalyst
phenylalanine derivatives
pyridinium chlorochromate
 
Description A diversity-oriented approach for the synthesis of various structurally different molecular frameworks from readily accessible and common precursors is described. A Claisen rearrangement followed by ring-closing metathesis or ethylene-promoted ring-closing enyne metathesis has been utilized as the key synthetic transformation to generate naphthoxepine derivatives. The ring-closing metathesis approach has also been used to generate spirocyclic compounds and the pleiadene framework.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2011-10-12T13:00:48Z
2011-12-15T09:16:08Z
2011-10-12T13:00:48Z
2011-12-15T09:16:08Z
2006
 
Type Review
 
Identifier CHEMISTRY-A EUROPEAN JOURNAL,12(31)8024-8038
0947-6539
http://dx.doi.org/10.1002/chem.200600540
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13777
http://hdl.handle.net/100/3012
 
Language en