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Bacterial degradation of phthalate isomers and their esters

DSpace at IIT Bombay

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Title Bacterial degradation of phthalate isomers and their esters
 
Creator VAMSEE-KRISHNA, C
PHALE, PS
 
Subject phthalate esters
toxicity
biodegradation
dioxygenases
genetic regulation
n-butyl phthalate
terephthalate 1,2-dioxygenase system
endocrine-disrupting chemicals
burkholderia-cepacia dbo1
micrococcus sp ygj1
sp strain pyr-1
protocatechuate 3,4-dioxygenase
di-2-ethylhexyl phthalate
anaerobic degradation
pseudomonas-cepacia
 
Description Phthalate isomers and their esters are used heavily in various industries. Excess use and leaching from the product pose them as major pollutants. These chemicals are toxic, teratogenic, mutagenic and carcinogenic in nature. Various aspects like toxicity, diversity in the aerobic bacterial degradation, enzymes and genetic organization of the metabolic pathways from various bacterial strains are reviewed here. Degradation of these esters proceeds by the action of esterases to form phthalate isomers, which are converted to dihydroxylated intermediates by specific and inducible phthalate isomer dioxygenases. Metabolic pathways of phthalate isomers converge at 3,4-dihydroxybenzoic acid, which undergoes either ortho-or meta-ring cleavage and subsequently metabolized to the central carbon pathway intermediates. The genes involved in the degradation are arranged in operons present either on plasmid or chromosome or both, and induced by specific phthalate isomer. Understanding metabolic pathways, diversity and their genetic regulation may help in constructing bacterial strains through genetic engineering approach for effective bioremediation and environmental clean up.
 
Publisher SPRINGER
 
Date 2011-10-13T19:28:24Z
2011-12-15T09:16:08Z
2011-10-13T19:28:24Z
2011-12-15T09:16:08Z
2008
 
Type Review
 
Identifier INDIAN JOURNAL OF MICROBIOLOGY,48(1)19-34
0046-8991
http://dx.doi.org/10.1007/s12088-008-0003-8
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13829
http://hdl.handle.net/100/3013
 
Language en