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Protein aggregation: a perspective from amyloid and inclusion-body formation

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Title Protein aggregation: a perspective from amyloid and inclusion-body formation
 
Creator IDICULA-THOMAS, S
BALAJI, PV
 
Subject folding intermediates
molecular evolution
natively unfolded
protein folding
soluble recombinant proteins
formation in-vitro
escherichia-coli
fibril formation
conformational diseases
sequence determinants
molecular chaperones
secondary structure
catalytic domain
common mechanism
 
Description Over the past few decades, an overwhelmingly vast amount of research has been dedicated to understanding protein aggregation. This review summarizes the current understanding of protein aggregation from the viewpoint of its two important manifestations: formation of amyloid fibrils and inclusion bodies. The article summarizes the structure, mechanism of formation, predisposing factors and measures of overcoming inclusion body and amyloid formation. The protective role played by molecular evolution in curbing aggregation and results from recent studies on the prediction of aggregation rates based on primary structure have also been discussed.
 
Publisher CURRENT SCIENCE ASSN
 
Date 2011-10-12T14:18:06Z
2011-12-15T09:16:10Z
2011-10-12T14:18:06Z
2011-12-15T09:16:10Z
2007
 
Type Review
 
Identifier CURRENT SCIENCE,92(6)758-767
0011-3891
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13798
http://hdl.handle.net/100/3036
 
Language en