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The building block approach to unusual alpha-amino acid derivatives and peptides

DSpace at IIT Bombay

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Title The building block approach to unusual alpha-amino acid derivatives and peptides
 
Creator KOTHA, S
 
Subject constrained phenylalanine derivatives
miyaura coupling reaction
enyne metathesis reaction
diels-alder approach
organic-synthesis
tic derivatives
side-chain
metalated isocyanides
olefin metathesis
protein-structure
 
Description The building block approach was identified as a useful alternative to the commonly used Bucherer-Berg method for the preparation of cyclic unusual alpha-amino acid derivatives. The symmetrical building blocks were prepared by dialkylation of ethyl isocyano-acetate under solid-liquid phase transfer catalysis conditions while the unsymmetrical building blocks were prepared by a stepwise alkylation of the O'Donnell Schiff base. Metathesis reactions, Suzuki couplings, and cycloaddition reactions were utilized to assemble the building blocks.
 
Publisher AMER CHEMICAL SOC
 
Date 2011-10-13T23:17:25Z
2011-12-15T09:16:12Z
2011-10-13T23:17:25Z
2011-12-15T09:16:12Z
2003
 
Type Review
 
Identifier ACCOUNTS OF CHEMICAL RESEARCH,36(5)342-351
0001-4842
http://dx.doi.org/10.1021/ar020147q
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13875
http://hdl.handle.net/100/3042
 
Language en