Record Details

Synthetic organoselenium compounds as antioxidants: glutathione peroxidase activity

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Synthetic organoselenium compounds as antioxidants: glutathione peroxidase activity
 
Creator MUGESH, G
SINGH, HB
 
Subject crystal-structure
model
derivatives
diselenides
resolution
chemistry
mimetics
ebselen
 
Description Organoselenium compounds find applications in organic synthesis, materials synthesis, ligand chemistry and biologically relevant processes. This review deals with the use of various synthetic organoselenium compounds as mimics of glutathione peroxidase (GPx), a selenoenzyme which catalyses the reduction of a variety of hydroperoxides and protects the cell membranes from oxidative damage. The mechanism by which these compounds catalyse the reduction of peroxides is also reviewed. The cyclic selenenamides and diselenides with suitably positioned substituents exert their catalytic activity by a mechanism similar to that of the natural enzyme.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2011-10-13T23:35:42Z
2011-12-15T09:16:14Z
2011-10-13T23:35:42Z
2011-12-15T09:16:14Z
2000
 
Type Review
 
Identifier CHEMICAL SOCIETY REVIEWS,29(5)347-357
0306-0012
http://dx.doi.org/10.1039/a908114c
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13880
http://hdl.handle.net/100/3065
 
Language en