ICAR Research Data Repository for Knowledge Management
Post-assembly peptide modifications by chemical methods
DSpace at IIT Bombay
View Archive Info| Field | Value | |
| Title |
Post-assembly peptide modifications by chemical methods
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| Creator |
KOTHA, S
LAHIRI, K |
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| Subject |
amino-acid derivatives
ring-closing metathesis cross-coupling reaction diels-alder approach constrained phenylalanine derivatives optically-active benzocyclobutene serine-based cyclodepsipeptides 2+2+2 cycloaddition strategy enyne metathesis cyclic-peptides |
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| Description |
The demand for peptide drugs is increasing and in this context, "post-assembly (or post-translational) peptide modification strategies" by chemical Manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for post-translational peptide modifications.
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| Publisher |
BENTHAM SCIENCE PUBL LTD
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| Date |
2011-10-13T22:11:23Z
2011-12-15T09:16:15Z 2011-10-13T22:11:23Z 2011-12-15T09:16:15Z 2005 |
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| Type |
Review
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| Identifier |
CURRENT MEDICINAL CHEMISTRY,12(7)849-875
0929-8673 http://dx.doi.org/10.2174/0929867053507333 http://dspace.library.iitb.ac.in/xmlui/handle/10054/13864 http://hdl.handle.net/100/3074 |
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| Language |
en
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