Record Details

Transcriptional control of the gal/mel regulon of yeast saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Transcriptional control of the gal/mel regulon of yeast saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction
 
Creator BHAT, PJ
MURTHY, TVS
 
Subject kluyveromyces-lactis
gal4p-activated genes
glucose repression
gal4 protein
gal80p
induction
galactokinase
expression
pathway
inducer
 
Description In the yeast Saccharomyces cerevisiae, the interplay between Gal3p, Gal80p and Gal4p determines the transcriptional status of the genes needed for galactose utilization. The interaction between Gal80p and Gal4p has been studied in great detail; however, our understanding of the mechanism of Gal3p in transducing the signal from galactose to Gal4p has only begun to emerge recently. Historically, Gal3p was believed to be an enzyme (catalytic model) that converts galactose to an inducer or co-inducer, which was thought to interact with GAL80p, the repressor of the system. However, recent genetic analyses indicate an alternative 'protein-protein interaction model'. According to this model, Gal3p is activated by galactose, which leads to its interaction with Gal80p. Biochemical and genetic experiments that support this model provided new insights into how Gal3p interacts with the Gal80p-Gal4p complex, alleviates the repression of Gal80p and thus allows Gal4p to activate transcription. Recently, a galactose-independent signal was suggested to co-ordinate the induction of GAL genes with the energy status of the cell.
 
Publisher BLACKWELL SCIENCE LTD
 
Date 2011-10-14T11:30:51Z
2011-12-15T09:16:20Z
2011-10-14T11:30:51Z
2011-12-15T09:16:20Z
2001
 
Type Review
 
Identifier MOLECULAR MICROBIOLOGY,40(5)1059-1066
0950-382X
http://dx.doi.org/10.1046/j.1365-2958.2001.02421.x
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13907
http://hdl.handle.net/100/3108
 
Language en