Record Details

Manufacture of liposomes - a review

DSpace at IIT Bombay

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Field Value
 
Title Manufacture of liposomes - a review
 
Creator WATWE, RM
BELLARE, JR
 
Subject large unilamellar vesicles
lipid vesicles
amphotericin-b
phospholipid-vesicles
prolonged circulation
tissue distribution
cholesterol content
light-scattering
drug delivery
freeze-thaw
 
Description A brief introduction to liposomes and the methods of their preparation is presented. Various laboratory-scale and large-scale methods of preparation of liposomes are reviewed. They include some of the recent techniques like the 'bubble' method, microencapsulation, microfluidization, LLC method, ethanol injection, freon injection and detergent dialysis and the traditional methods like hydration, sonication and reverse phase evaporation. This paper also discusses the crucial problems like stability and quality control in the commercialization of liposomes and the methods (such as lyophilization and the various characterization techniques like electron microscopy and gel permeation chromatography) to overcome them, Also discussed is the mechanism of vesicle formation.
 
Publisher CURRENT SCIENCE ASSN
 
Date 2011-10-14T11:33:39Z
2011-12-15T09:16:20Z
2011-10-14T11:33:39Z
2011-12-15T09:16:20Z
1995
 
Type Review
 
Identifier CURRENT SCIENCE,68(7)715-724
0011-3891
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13908
http://hdl.handle.net/100/3109
 
Language en