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Advanced approach to polycyclics by a synergistic combination of enyne metathesis and diels-alder reaction

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Title Advanced approach to polycyclics by a synergistic combination of enyne metathesis and diels-alder reaction
 
Creator KOTHA, S
MESHRAM, M
TIWARI, A
 
Subject ring-closing enyne
amino-acid derivatives
combined claisen rearrangement
natural-product frameworks
olefin-metathesis
cross-metathesis
catalytic metathesis
beta-lactams
phenylalanine derivatives
propargylic position
 
Description Enyne metathesis (EM) has widely been used to prepare various synthetic and natural products. Further, a sequential use of EM and Diels-Alder (DA) reactions generates highly functionalized and intricate polycarbocycles and heterocyclic frameworks. In this critical review we describe the application of a unique combination of EM and DA reactions to prepare various amino acid derivatives, natural products and heterocycles. Some of the heterocyclic targets include cyclic peroxides, siloxanes and various nitrogen (or oxygen) containing compounds. Use of ethylene and cyclooctadiene (COD) for improving the yield of EM products are also discussed (69 references).
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2011-10-15T06:23:03Z
2011-12-15T09:16:20Z
2011-10-15T06:23:03Z
2011-12-15T09:16:20Z
2009
 
Type Review
 
Identifier CHEMICAL SOCIETY REVIEWS,38(7)2065-2092
0306-0012
http://dx.doi.org/10.1039/b810094m
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13935
http://hdl.handle.net/100/3110
 
Language en