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Surface chemistry of the lung surfactant system: techniques for in vitro evaluation

DSpace at IIT Bombay

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Title Surface chemistry of the lung surfactant system: techniques for in vitro evaluation
 
Creator BANERJEE, R
 
Subject model pulmonary surfactant
scanning force microscopy
captive bubble method
air-water-interface
sp-c
dipalmitoyl phosphatidylcholine
sp-b
protein
films
monolayers
 
Description Our lungs. are lined by a surface-active material which is responsible for lowering surface tension to near zero values on expiration, and preventing lung collapse. The presence of a functional lung surfactant reduces the work of breathing. Respiratory Distress Syndrome (RDS) is a disease due to lack of lung surfactant in pre-term babies (born before nine months). Surfactant dysfunction also occurs in many adult respiratory diseases like adult respiratory distress syndrome, asthma and chronic bronchitis. The surface properties of surfactants are important factors, which determine their suitability for exogenous therapy in conditions of surfactant dysfunction. Various in vitro techniques, commonly used in surface science, are modified to suit them for application to the lung surfactant system - for study of the surface properties of surfactants under dynamic conditions, which simulate those present in vivo in the pulmonary system. This paper outlines some of these techniques as applied to the lung surfactant system and discusses the relevance of surface properties to pulmonary physiology.
 
Publisher CURRENT SCIENCE ASSN
 
Date 2011-10-14T11:44:59Z
2011-12-15T09:16:20Z
2011-10-14T11:44:59Z
2011-12-15T09:16:20Z
2002
 
Type Review
 
Identifier CURRENT SCIENCE,82(4)420-428
0011-3891
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13912
http://hdl.handle.net/100/3114
 
Language en