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Membrane current and potential change during neurotransmission in smooth-muscle

DSpace at IIT Bombay

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Title Membrane current and potential change during neurotransmission in smooth-muscle
 
Creator MANCHANDA, R
 
Subject mouse vas-deferens
sympathetic neuroeffector junction
guinea-pig
neuromuscular-junction
transmitter action
time course
arterioles
transmission
varicosities
secretion
 
Description Smooth muscle cells are electrically coupled to one another in a syncytium, and this renders their electrophysiology during neurotransmission strikingly different from that at other synapses. The postjunctional depolarizing responses of sympathetically innervated smooth muscle such as the vas deferens, particularly, the excitatory junction potentials (EJPs), possess intriguing properties which for several years have resisted explanation. A principal issue has been the temporal relationship of transmitter-generated membrane current to the resulting potential change, which seems to differ depending upon whether transmitter release is spontaneous or is nerve-stimulation-evoked. Accordingly, smooth muscle electrical properties appear to change with different patterns of transmitter release. Until some years ago this relationship was an area of uncertainty, firstly because transmitter-activated membrane current could not be measured directly and secondly because intracellular membrane potential measurements gave rise to conflicting results. Many of the uncertainties have now been resolved with refinements in techniques of measurement that have allowed membrane current time course during neurotransmission to be estimated. As a result, our understanding of smooth muscle electrical properties has been clarified and deepened. These developments are outlined in this review, and it is shown how our comprehension of neurotransmission has at every stage been influenced strongly by the techniques adopted for investigation.
 
Publisher CURRENT SCIENCE ASSN
 
Date 2011-10-14T11:56:15Z
2011-12-15T09:16:20Z
2011-10-14T11:56:15Z
2011-12-15T09:16:20Z
1995
 
Type Review
 
Identifier CURRENT SCIENCE,69(2)140-150
0011-3891
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13915
http://hdl.handle.net/100/3118
 
Language en