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Neurotransmission by atp: new insights, novel mechanisms

DSpace at IIT Bombay

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Title Neurotransmission by atp: new insights, novel mechanisms
 
Creator GHILDYAL, P
MANCHANDA, R
 
Subject vas-deferens
extracellular atp
p2x receptors
ecto-atpase
urinary-bladder
purinergic neurotransmission
adenosine-triphosphate
p-2x receptors
smooth-muscle
rat
 
Description Purines have long been known for their roles in extracellular signaling. One of the most interesting functions to come to light recently has been the involvement, particularly of adenosine 5'-triphosphate (ATP), as a neurotransmitter in the central and the sympathetic nervous system. ATP is stored in and released from synaptic nerve terminals, like other neurotransmitters, and is known to act post-synaptically via specific rapidly-conducting, ligand-gated ion channels, the P-2X receptors. Another interesting feature is the discovery that ATP is widely found to be a "co-transmitter" at the same synapses in combination with other neurotransmitters such as noradrenaline, acetylcholine, and GABA, altering our picture of the biophysics and biochemistry of neurotransmission at these synapses. We describe here these and other aspects of neurotransmission by ATP being investigated vigorously today, including recent findings on P-2X receptors and those on the synaptic inactivation of ATP by ecto-ATPase. We conclude by pointing out possible pharmacological and. clinical implications of neurotransmission by ATP.
 
Publisher NATL INST SCIENCE COMMUNICATION
 
Date 2011-10-15T08:51:27Z
2011-12-15T09:16:24Z
2011-10-15T08:51:27Z
2011-12-15T09:16:24Z
2002
 
Type Review
 
Identifier INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS,39(3)137-147
0301-1208
http://dspace.library.iitb.ac.in/xmlui/handle/10054/13962
http://hdl.handle.net/100/3154
 
Language en