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Modification of pattern of excitatory junction currents in the guinea pig vas deferens by the gap junction uncoupler heptano

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Title Modification of pattern of excitatory junction currents in the guinea pig vas deferens by the gap junction uncoupler heptano
 
Creator MANCHANDA, R
VENKATESWARLU, K
 
Subject bioelectric potentials
cytology
neurology
agents
phase composition
 
Description Extracellularly recorded excitatory junction currents (EJCs) produced by neurotransmission to the smooth muscle of the vas deferens have a varied phasic composition. They can be positive going (p-EJC), negative going (n-EJC) or biphasic (b-EJC) from one event to the next. The phasicity is believed to depend upon the syncytial properties of the smooth muscle cells. The authors have investigated the effects of 1-heptanol, an intercellular uncoupling agent, on the phasicity of EJCs. In control Krebs solution EJCs with a positive phase (p- and b-EJCs) occurred as a considerable fraction of total EJCs recorded. Following the application of 2 mM heptanol for 2-3 min., the occurrence of p-and b-EJCs decreased markedly while that of n-EJCs increased. The change was reversible and repeatable. Heptanol did not, however, affect the prejunctional nerve action potential. These bioelectric results can be explained in terms of the specific uncoupling of smooth muscle cells by heptanol.
 
Publisher IEEE
 
Date 2009-06-16T04:30:41Z
2011-11-28T08:30:14Z
2011-12-15T09:57:41Z
2009-06-16T04:30:41Z
2011-11-28T08:30:14Z
2011-12-15T09:57:41Z
1996
 
Identifier Proceedings of the 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Amsterdam, Netherlands, 31 Oct.-3 Nov. 1996, 1769 - 1770
0-7803-3811-1
10.1109/IEMBS.1996.647653
http://hdl.handle.net/10054/1496
http://dspace.library.iitb.ac.in/xmlui/handle/10054/1496
 
Language en