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Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis

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Title Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis
 
Creator SUBBARAYAN, M
SHETTY, SJ
SRIVASTAVA, TS
NORONHA, OPD
SAMUEL, AM
MUKHTAR, H
 
Subject starburst polyamidoamine dendrimers
photodynamic therapy
efficient transfer
cascade polymers
contrast agents
tissue
cells
tc-99m-labeled dendritic porphyrin
scintiimaging
photodynamic therapy
photodynamic diagnosis
 
Description We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeIed them with Tc-99m. These Tc-99m-labeled porphyrins were administered to C-6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications.
 
Publisher ACADEMIC PRESS INC
 
Date 2011-07-12T13:22:41Z
2011-12-26T12:48:54Z
2011-12-27T05:34:25Z
2011-07-12T13:22:41Z
2011-12-26T12:48:54Z
2011-12-27T05:34:25Z
2001
 
Type Article
 
Identifier BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 281(1), 32-36
0006-291X
http://dx.doi.org/10.1006/bbrc.2001.4289
http://dspace.library.iitb.ac.in/xmlui/handle/10054/3336
http://hdl.handle.net/10054/3336
 
Language en