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Use of Subcritical CO(2) for Production of Ultrafine Particles by Pressure Reduction of Gas-Expanded Organic Liquids

DSpace at IIT Bombay

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Title Use of Subcritical CO(2) for Production of Ultrafine Particles by Pressure Reduction of Gas-Expanded Organic Liquids
 
Creator DALVI, SV
MUKHOPADHYAY, M
 
Subject compressed fluid antisolvent
ress-sc process
rapid expansion
supercritical solutions
carbon-dioxide
precipitation
behavior
recrystallization
crystallization
cholesterol
 
Description In this paper we illustrate the use of subcritical carbon dioxide to precipitate ultrafine solid particles. The process has been developed to attain rapid, high, and uniform supersaturation by drastic reduction of the solution temperature and is named PPRGEL (precipitation by pressure reduction of gas-expanded liquids). Rapid pressure reduction over a CO(2)-expanded liquid solution from 40-70 to 1 bar at 303 K reduces the solution temperature by 30-80 K in a very short span of time (0.5-1.5 min) and facilitates precipitation of ultrafine particles. The process performance has been evaluated for particle production of cholesterol from 100 mL of its acetone and ethanol solutions (5-10 mg/mL) at 40-70 bar and 303 K using a 1 L high-pressure vessel. Particles with a size range of 200 nm to 7 mu m and morphologies of near-spherical to needles have been produced with a change in operating conditions.
 
Publisher AMER CHEMICAL SOC
 
Date 2011-07-15T04:19:26Z
2011-12-26T12:49:14Z
2011-12-27T05:35:03Z
2011-07-15T04:19:26Z
2011-12-26T12:49:14Z
2011-12-27T05:35:03Z
2009
 
Type Article
 
Identifier INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 48(12), 5696-5707
0888-5885
http://dx.doi.org/10.1021/ie900132r
http://dspace.library.iitb.ac.in/xmlui/handle/10054/4152
http://hdl.handle.net/10054/4152
 
Language en