Shock wave driven liquid microjets for drug delivery
DSpace at IIT Bombay
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Title |
Shock wave driven liquid microjets for drug delivery
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Creator |
MENEZES, V
KUMAR, S TAKAYAMA, K |
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Subject |
expression
dna |
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Description |
A nonintrusive, minimally invasive, needle-less technique to deliver liquids into soft targets is presented. The technique uses a laser-induced shock wave to drive a liquid microjet at a very high speed such that the jet has sufficient momentum to penetrate soft targets. The method can be used to deliver liquid drugs into soft tissues in the human body. The liquid to be delivered is sandwiched between 200 mu m thick aluminum foil and a base plate with a perforation of 100 mu m diameter. The aluminum foil is ablated using an Nd:YAG laser beam in order to launch a shock wave through it. The shock wave from the foil is transmitted to the sandwiched liquid, which becomes pressurized by the shock propagation and emanates as a microjet through the perforation in the base plate. The microjet thus generated has a steady, average speed of over 200 m/s. The technique has been tested on gelatin models (5% gelatin), in which the jet penetrated to a depth of more than a millimeter. (C) 2009 [doi:10.1063/1.3245320]
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Publisher |
AMER INST PHYSICS
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Date |
2011-07-16T14:14:59Z
2011-12-26T12:49:48Z 2011-12-27T05:35:32Z 2011-07-16T14:14:59Z 2011-12-26T12:49:48Z 2011-12-27T05:35:32Z 2009 |
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Type |
Article
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Identifier |
JOURNAL OF APPLIED PHYSICS, 106(8), -
0021-8979 http://dx.doi.org/10.1063/1.3245320 http://dspace.library.iitb.ac.in/xmlui/handle/10054/4448 http://hdl.handle.net/10054/4448 |
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Language |
en
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