Record Details

Nano-in-micro alginate based hybrid particles

DSpace at IIT Bombay

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Field Value
 
Title Nano-in-micro alginate based hybrid particles
 
Creator JOSHI, A
KEERTHIPRASAD, R
JAYANT, RD
SRIVASTAVA, R
 
Subject 2-step desolvation method
gelatin nanoparticles
calcium-carbonate
delivery-system
microspheres
encapsulation
polymerization
microcapsules
phosphate
cells
nano-in-micro'
gelatin
caco(3)
alginate
dexamethasone
lbl
 
Description Novel template containing 'Nanoparticles (gelatin and CaCO(3)) embedded in Microspheres' ('Nano-in-micro') was developed using atomization. Dexamethasone loaded gelatin nanoparticles, fluorescein isothiocyanate-dextran (FITC-dex) loaded CaCO(3) nanoparticles and alginate based 'Nano-in-micro' system were prepared and characterized using optical microscopy, SEM, TEM. DLS, zeta potential, CLSM and FTIR. The results indicate that spherical, non-aggregating, 'nano-in-micro' particles (5-60 mu m) can be prepared using atomization technique. Dexamethasone release from gelatin nanoparticles and 'nano-in-micro' systems indicated a decrease in burst release in the order: uncoated (24%) > coated (18%) > 'nano-in-micro' system (1:4 ratio) (17%). The sustained release decreased in order of 'nano-in-micro' (1:4 ratio) (14 days) > coated nanoparticles (9 days)> uncoated nanoparticles (4 days) for 95% drug release. FITC-dex loading and release from CaCO(3) nanoparticles were found to be molecular weight dependent. Thus, 'nano-in-micro' systems show possibility for use as drug release vehicles, biosensors and multifunctional systems.
 
Publisher ELSEVIER SCI LTD
 
Date 2011-07-22T08:27:37Z
2011-12-26T12:52:21Z
2011-12-27T05:35:32Z
2011-07-22T08:27:37Z
2011-12-26T12:52:21Z
2011-12-27T05:35:32Z
2010
 
Type Article
 
Identifier CARBOHYDRATE POLYMERS, 81(4), 790-798
0144-8617
http://dx.doi.org/10.1016/j.carbpol.2010.03.050
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6165
http://hdl.handle.net/10054/6165
 
Language en