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Scoring of surface parameters of physiological relevance to surfactant therapy in respiratory distress syndrome

DSpace at IIT Bombay

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Title Scoring of surface parameters of physiological relevance to surfactant therapy in respiratory distress syndrome
 
Creator BANERJEE, R
BELLARE, JR
 
Subject dynamic interfacial properties
proteins sp-b
pulmonary surfactant
lung surfactant
dipalmitoyl phosphatidylcholine
phosphonolipid analogs
excess films
sp-c
phospholipids
monolayers
surface pressure
wilhelmy balance
 
Description The Wilhelmy balance was used for in vitro testing of surface parameters of surfactants used for respiratory distress syndrome therapy. Two commercial protein-free surfactants, ALEC and Exosurf, were compared with pure forms of the three main phospholipids in natural surfactants, dipalmitoyl phosphatidylcholine (PC), phosphatidylglycerol (PG), and phosphatidylethanolamine (PE), and their binary mixtures, PC with PE and PG each in the ratio 2:3. Surface excess films (15 Angstrom (2)/molecule) were compressed at 1.2 cycles/min past collapse to a compression ratio of 4:1. The maximum surface pressure, spreading time, compressibility, respreading ratio, recruitment index, and hysteresis area were compared. A consolidated list of criteria for selection of suitable surfactants was compiled from the literature. A relative scoring system was devised for comparison based on these criteria. PC/PG (2:3) performed the best as it fulfilled all the criteria and obtained the highest relative score. Exosurf also performed well, except on the respreading criterion. ALEC and PC/PE were equivalent in their performance and performed well, except on two criteria: hysteresis area and recruitment index. Thus the scoring system proposed here proved valuable to rate the overall efficacy as well as relative merits of surfactant formulations.
 
Publisher AMER PHYSIOLOGICAL SOC
 
Date 2011-07-17T01:33:41Z
2011-12-26T12:50:03Z
2011-12-27T05:35:59Z
2011-07-17T01:33:41Z
2011-12-26T12:50:03Z
2011-12-27T05:35:59Z
2001
 
Type Article
 
Identifier JOURNAL OF APPLIED PHYSIOLOGY, 90(4), 1447-1454
8750-7587
http://dspace.library.iitb.ac.in/xmlui/handle/10054/4581
http://hdl.handle.net/10054/4581
 
Language en