Record Details

From sliding nucleosomes to twirling DNA motors

DSpace at IIT Bombay

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Title From sliding nucleosomes to twirling DNA motors
 
Creator KULIC, IM
THAOKAR, R
SCHIESSEL, H
 
Subject positioned nucleosomes
histone octamer
brownian motors
target sites
sequences
chromatin
equilibrium
ligands
binding
single
nucleosome
thermal ratchet
dna elasticity
plasmid
 
Description The sliding of DNA-wrapped protein cylinders, so-called nucleosomes, along DNA is a mechanism presumably involved in exposing wrapped eucaryotic DNA to the molecular machinery. On the other hand, a self-propelling DNA minicircle is an example of a nanotechnological device that can be driven by temperature oscillations employing the ratchet effect. We show parallels between the two systems by demonstrating that a nucleosome in principle could also be turned into such an externally driven nanodevice; in this case the nucleosome would slide in directed fashion along DNA. We demonstrate, however, that the high friction between the DNA and the protein cylinder renders this idea unfeasible.
 
Publisher AMER SCIENTIFIC PUBLISHERS
 
Date 2011-07-17T02:41:08Z
2011-12-26T12:50:04Z
2011-12-27T05:36:02Z
2011-07-17T02:41:08Z
2011-12-26T12:50:04Z
2011-12-27T05:36:02Z
2006
 
Type Article
 
Identifier JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE, 3(6), 912-921
1546-1955
http://dx.doi.org/10.1166/jctn.2006.007
http://dspace.library.iitb.ac.in/xmlui/handle/10054/4597
http://hdl.handle.net/10054/4597
 
Language en