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Galactose-1-phosphate is a regulator of inositol monophosphatase: a fact or a fiction?

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Title Galactose-1-phosphate is a regulator of inositol monophosphatase: a fact or a fiction?
 
Creator BHAT, PJ
 
Subject udp-glucose pyrophosphorylase
saccharomyces-cerevisiae
bipolar disorder
galactose metabolism
brain
myoinositol
gene
lithium
yeast
 
Description Classic galactosemia is due to the deficiency of galactose-1-phosphate uridyl transferase and is transmitted as an autosomal recessive disorder. Patients suffering from classic galactosemia display acute symptoms such as poor growth, feeding difficulties, jaundice, hepatomegaly etc., which disappear when the individual is on galactose free diet. However, these patients continue to suffer from defects such as neurological disturbances and ovarian dysfunction, due to the accumulation of galactose-1-phosphate, which is a normal intermediate of galactose metabolism. The biochemical mechanism of galactose-1-phosphate mediated toxicity is still an enigma. Recent experiments strongly suggest that galactose-1-phosphate is also a substrate for inositol monophosphatase (IMPase). Phosphatidylinositol bisphosphate {PI(P)2} dependent signaling serves as a second messenger for several neurotransmitters in the brain. Therefore, the brain is critically dependent on IMPase for the supply of free inositol in order to sustain {PI(P)2} signaling. Circumstantial evidence strongly supports the possibility that being a substrate, galactose-1-phosphate could modulate IMPase function in vivo. The implication of this idea is discussed in relation to classic galactosemia as well as bipolar disorder, which has been thought to be due to the hyper-activation of {PI(P)2} mediated second messenger pathways(s). (C) 2002 . .
 
Publisher CHURCHILL LIVINGSTONE
 
Date 2011-07-20T10:16:17Z
2011-12-26T12:51:26Z
2011-12-27T05:36:13Z
2011-07-20T10:16:17Z
2011-12-26T12:51:26Z
2011-12-27T05:36:13Z
2003
 
Type Article
 
Identifier MEDICAL HYPOTHESES, 60(1), 123-128
0306-9877
http://dx.doi.org/10.1016/S0306-9877(02)00347-X
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5439
http://hdl.handle.net/10054/5439
 
Language en