Record Details

Ferrite-Silica-Insulin Nanocomposites (FeSINC) for Glucose Reduction

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Ferrite-Silica-Insulin Nanocomposites (FeSINC) for Glucose Reduction
 
Creator DWIVEDI, N
ARUNAGIRINATHAN
SHARMA, S
BELLARE, J
 
Subject controlled drug-delivery
raman-spectroscopy
nanoparticles
systems
carrier
spheres
 
Description Proteins find a more stable environment upon encapsulation in a silica host, because of the polymeric silica frame that grows around the macromolecule and protects them from denaturation. Silica-insulin nanocomposite (SINC) and ferrite-coated SINC (FeSINC) was prepared by polyelectrolytic condensation of silica precursor on insulin and they were studied for their ability to control glucose levels. SINC was prepared by acid-base-catalyzed polymerization in the presence Of insulin at room temperature by a modified Stober's process. FeSINC nanoparticles were prepared by coprecipitation of both ferric and ferrous salts on the bovine bovine insulin loaded silica nanoparticle. The presence of ferrite coating in FeSINC was identified using a vibrating sample magnetometer and quantified from XRF study. The intermolecular interactions in these nanocomposites were studied by FTIR and Raman spectroscopy. All in vivo study indicated that FeSINC was biologically active in reducing glucose levels as compared to SINC.
 
Publisher AMER CHEMICAL SOC
 
Date 2011-07-14T03:59:22Z
2011-12-26T12:47:33Z
2011-12-27T05:36:18Z
2011-07-14T03:59:22Z
2011-12-26T12:47:33Z
2011-12-27T05:36:18Z
2010
 
Type Article
 
Identifier LANGMUIR, 26(1), 357-361
0743-7463
http://dx.doi.org/10.1021/la902094c
http://dspace.library.iitb.ac.in/xmlui/handle/10054/3854
http://hdl.handle.net/10054/3854
 
Language en