Equation of state of looped DNA
DSpace at IIT Bombay
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Title |
Equation of state of looped DNA
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Creator |
KULIC, IM
MOHRBACH, H THAOKAR, R SCHIESSEL, H |
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Subject |
supercoiled dna
entropic elasticity stretching dna circular dnas stiff chains molecule polymer model twist extension |
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Description |
We derive the equation of state of DNA under tension that features a loop. Such loops occur transiently during DNA condensation in the presence of multivalent ions or permanently through sliding protein linkers such as condensin. The force-extension relation of such looped-DNA modeled as a wormlike chain is calculated via path integration in the semiclassical limit. This allows us to rigorously determine the high stretching asymptotics. Notably the functional form of the force-extension curve resembles that of straight DNA, yet with a strongly renormalized apparent persistence length. We also present analogous results for DNA under tension with several protein-induced kinks and/or loops. That means that the experimentally extracted single-molecule elasticity does not necessarily only reflect the bare DNA stiffness, but can also contain additional contributions that depend on the overall chain conformation and length.
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Publisher |
AMERICAN PHYSICAL SOC
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Date |
2011-07-17T13:20:23Z
2011-12-26T12:50:19Z 2011-12-27T05:36:33Z 2011-07-17T13:20:23Z 2011-12-26T12:50:19Z 2011-12-27T05:36:33Z 2007 |
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Type |
Article
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Identifier |
PHYSICAL REVIEW E, 75(1), -
1539-3755 http://dx.doi.org/10.1103/PhysRevE.75.011913 http://dspace.library.iitb.ac.in/xmlui/handle/10054/4741 http://hdl.handle.net/10054/4741 |
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Language |
en
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