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Equation of state of looped DNA

DSpace at IIT Bombay

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Field Value
 
Title Equation of state of looped DNA
 
Creator KULIC, IM
MOHRBACH, H
THAOKAR, R
SCHIESSEL, H
 
Subject supercoiled dna
entropic elasticity
stretching dna
circular dnas
stiff chains
molecule
polymer
model
twist
extension
 
Description We derive the equation of state of DNA under tension that features a loop. Such loops occur transiently during DNA condensation in the presence of multivalent ions or permanently through sliding protein linkers such as condensin. The force-extension relation of such looped-DNA modeled as a wormlike chain is calculated via path integration in the semiclassical limit. This allows us to rigorously determine the high stretching asymptotics. Notably the functional form of the force-extension curve resembles that of straight DNA, yet with a strongly renormalized apparent persistence length. We also present analogous results for DNA under tension with several protein-induced kinks and/or loops. That means that the experimentally extracted single-molecule elasticity does not necessarily only reflect the bare DNA stiffness, but can also contain additional contributions that depend on the overall chain conformation and length.
 
Publisher AMERICAN PHYSICAL SOC
 
Date 2011-07-17T13:20:23Z
2011-12-26T12:50:19Z
2011-12-27T05:36:33Z
2011-07-17T13:20:23Z
2011-12-26T12:50:19Z
2011-12-27T05:36:33Z
2007
 
Type Article
 
Identifier PHYSICAL REVIEW E, 75(1), -
1539-3755
http://dx.doi.org/10.1103/PhysRevE.75.011913
http://dspace.library.iitb.ac.in/xmlui/handle/10054/4741
http://hdl.handle.net/10054/4741
 
Language en