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Inhibitory effects of mycobacterial cell wall lipids on bovine lung surfactant extract: An in vitro study at the air-aqueous interface

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Title Inhibitory effects of mycobacterial cell wall lipids on bovine lung surfactant extract: An in vitro study at the air-aqueous interface
 
Creator CHIMOTE, G
BANERJEE, R
 
Subject pulmonary surfactant
cord factor
dipalmitoylphosphatidylcholine monolayers
mycolic acid
tuberculosis
albumin
serum
dysfunction
mechanisms
adsorption
lung surfactant dysfunction
pulmonary tuberculosis
mycolic acid
cord factor
 
Description Lung surfactant is a lipoprotein Mixture synthesized by the type [I alveolar cells in the lungs and lines the air-aqueous interface. It is essential for stabilizing the pulmonary alveoli. Deficiency or dysfunction of the surfactant due to chemicals or toxins results in alveolar collapse and if untreated leads to respiratory distress. In pulmonary tuberculosis, Mycobacterium tuberculosis bacteria reside in the alveoli, in close physical proximity with the alveolar surfactant. The surface active mycobacterial cell wall lipids may easily detach from bacterial cell wall and interact with surfactant components altering their surface activity. In this study, effects of mycolic acid and cord factor (the abundant surface lipids of mycobacterial cell wall) oil the surface activity of modified bovine surfactant extract (Survanta (TM)) were characterized in vitro using the Wilhelmy surface balance at physiological temperature (37 degrees C) and pH 7.4. Inhibitory effects of mycobacterial cell wall lipids oil the terminal airway surfactant were evaluated using a capillary surfactometer. Addition of graded amounts of mycolic acid and cord factor significantly increased the minimum Surface tension Of survanta (TM) monolayer from
 
Publisher ELSEVIER SCIENCE BV
 
Date 2011-07-25T07:49:28Z
2011-12-26T12:50:20Z
2011-12-27T05:36:35Z
2011-07-25T07:49:28Z
2011-12-26T12:50:20Z
2011-12-27T05:36:35Z
2009
 
Type Article
 
Identifier COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 33(1-3), 7-14
0927-7757
http://dx.doi.org/10.1016/j.colsurfa.2008.12.002
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6679
http://hdl.handle.net/10054/6679
 
Language en