A HIGH YIELDING SYNTHESIS OF (25R)-SPIRO[CYCLOPROPANE-1,2'-(19-NOR-SPIROST-4-EN-22-ALPHA-O)-3-ONE]
DSpace at IIT Bombay
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Title |
A HIGH YIELDING SYNTHESIS OF (25R)-SPIRO[CYCLOPROPANE-1,2'-(19-NOR-SPIROST-4-EN-22-ALPHA-O)-3-ONE]
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Creator |
DESAI, UR
TRIVEDI, GK |
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Description |
The synthesis of title compound (1) by a series of functional group transformations in a high overall yield from the commercially available diosgenin is described. The synthesis requires 5-alpha, 6-beta-bromohydrin formation, radical-initiated ring formation, regioselective opening of the epoxy ring, and regioselective cyclopropanation as crucial steps.
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Publisher |
COUNCIL SCIENTIFIC INDUSTRIAL RESEARCH
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Date |
2011-07-20T11:36:22Z
2011-12-26T12:51:27Z 2011-12-27T05:36:39Z 2011-07-20T11:36:22Z 2011-12-26T12:51:27Z 2011-12-27T05:36:39Z 1991 |
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Type |
Article
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Identifier |
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 30(7), 635-638
0376-4699 http://dspace.library.iitb.ac.in/xmlui/handle/10054/5460 http://hdl.handle.net/10054/5460 |
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Language |
en
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