Record Details

Data mining of VDJ genes reveals interesting clues

DSpace at IIT Bombay

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Field Value
 
Title Data mining of VDJ genes reveals interesting clues
 
Creator JOSHI, RR
GUPTA, VK
 
Subject biosynthesis of immunoglobulins
hierarchical clustering
sequence-alignment
 
Description Hypervariability of the complementary determining regions in characteristic structure of Immnoglobulins and the distinct, cell-specific expressions of the genes coding for this important class of proteins pose intriguing problems in experimental and computational/informatics research requiring a special approach different from those for the other proteins. We present here an Average Linkage Hierarchical Clustering of the Homosapien VIA genes and the Immunoglobulin polypeptides generated by them using special kind of data structures and correlation matrices in place of the microarray data. The results reveal interesting clues on the heterogeneity of exon-intron locations in these gene-families and its possible role in hypervariability of the Immunoglobulins.
 
Publisher BENTHAM SCIENCE PUBL LTD
 
Date 2011-07-18T23:43:13Z
2011-12-26T12:50:53Z
2011-12-27T05:37:04Z
2011-07-18T23:43:13Z
2011-12-26T12:50:53Z
2011-12-27T05:37:04Z
2006
 
Type Article
 
Identifier PROTEIN AND PEPTIDE LETTERS, 13(6), 587-593
0929-8665
http://dx.doi.org/10.2174/092986606777145797
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5104
http://hdl.handle.net/10054/5104
 
Language en