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Design and synthesis of spirocyclics via the Diels-Alder reaction and ring-opening cross-metathesis as key steps

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Title Design and synthesis of spirocyclics via the Diels-Alder reaction and ring-opening cross-metathesis as key steps
 
Creator KOTHA, S
DEB, AC
CHATTOPADHYAY, S
 
Subject alpha-ethenylidene cyclanones
amino-acid derivatives
enyne metathesis
closing metathesis
phenylalanine derivatives
efficient synthesis
olefin metathesis
reagents
spirocycles
rocm
diels-alder
grubbs' catalyst
quinones
spiro-diene
fenestranes
 
Description Ring-opening-cross-metathesis (ROCM) reaction has been used to prepare spiro-indane derivatives containing six rings. The Diels-Alder (DA) chemistry of indan-2-spiro(cyclopenta-2,4-diene) I with various dienophiles such as 1,4-benzoquinone and its derivatives gave the corresponding DA products in moderate to good yields. Also, we report an improved procedure for preparation of the spiro-diene I using phase-transfer catalysis (PTC) conditions.
 
Publisher BENTHAM SCIENCE PUBL LTD
 
Date 2011-07-18T23:47:26Z
2011-12-26T12:50:53Z
2011-12-27T05:37:04Z
2011-07-18T23:47:26Z
2011-12-26T12:50:53Z
2011-12-27T05:37:04Z
2006
 
Type Article
 
Identifier LETTERS IN ORGANIC CHEMISTRY, 3(2), 128-134
1570-1786
http://dx.doi.org/10.2174/157017806775224350
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5105
http://hdl.handle.net/10054/5105
 
Language en