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Gibbs Sampling Shows Possibilities of B-Cell Epitope Signatures

DSpace at IIT Bombay

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Title Gibbs Sampling Shows Possibilities of B-Cell Epitope Signatures
 
Creator JOSHI, RR
HIRA, U
SURI, D
 
Subject amino-acid-composition
protease cleavage sites
predicting signal peptides
support vector machine
drug design
web-server
computational approach
evolution information
membrane-proteins
binding mechanism
 
Description We have attempted finding common sequential patterns among protein antigens. For this, we have used Gibbs multiple motif sampler on the set of all non-redundant antigenic sequences available in curated databanks. Several sequential motifs are obtained on these sequences when the amino acids are represented according to their similarity clusters. Significantly high proportions of known B-cell epitope sites are found within or adjacent to these motifs, thus indicating a possibility of linear epitope signatures. These findings may offer important applications in synthesis of peptide vaccines. A predictive example in this regard is presented.
 
Publisher BENTHAM SCIENCE PUBL LTD
 
Date 2011-07-18T23:53:03Z
2011-12-26T12:50:53Z
2011-12-27T05:37:05Z
2011-07-18T23:53:03Z
2011-12-26T12:50:53Z
2011-12-27T05:37:05Z
2009
 
Type Article
 
Identifier PROTEIN AND PEPTIDE LETTERS, 16(11), 1393-1398
0929-8665
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5107
http://hdl.handle.net/10054/5107
 
Language en