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Dynamic model of Escherichia coli tryptophan operon shows an optimal structural design

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Title Dynamic model of Escherichia coli tryptophan operon shows an optimal structural design
 
Creator BHARTIYA, S
RAWOOL, S
VENKATESH, KV
 
Subject trp operon
feedback inhibition
repressor
aporepressor
attenuation
trp operon
transcriptional control
dynamic modeling
tryptophan
feedback repression
 
Description A mathematical model has been developed to study the effect of external tryptophan on the trp operon. The model accounts for the effect of feedback repression by tryptophan through the Hill equation. We demonstrate that the trp operon maintains an intracellular steady-state concentration in a fivefold range irrespective of extracellular conditions. Dynamic behavior of the trp operon corresponding to varying levels of extracellular tryptophan illustrates the adaptive nature of regulation. Depending on the external tryptophan level in the medium, the transient response ranges from a rapid and underdamped to a sluggish and highly overdamped response. To test model fidelity, simulation results are compared with experimental data available in the literature. We further demonstrate the significance of the biological structure of the operon on the overall performance. Our analysis suggests that the tryptophan operon has evolved to a truly optimal design.
 
Publisher BLACKWELL PUBLISHING LTD
 
Date 2011-07-19T05:17:36Z
2011-12-26T12:51:01Z
2011-12-27T05:37:19Z
2011-07-19T05:17:36Z
2011-12-26T12:51:01Z
2011-12-27T05:37:19Z
2003
 
Type Article
 
Identifier EUROPEAN JOURNAL OF BIOCHEMISTRY, 270(12), 2644-2651
0014-2956
http://dx.doi.org/10.1046/j.1432-1033.2003.03641.x
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5185
http://hdl.handle.net/10054/5185
 
Language en