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NEW STEROID HAPTENS FOR RADIOIMMUNOASSAY - SYNTHESIS OF STEROIDS SUBSTITUTED WITH THIOETHER OR ESTER LINKAGES AT THE 2-ALPHA-POSITION

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Title NEW STEROID HAPTENS FOR RADIOIMMUNOASSAY - SYNTHESIS OF STEROIDS SUBSTITUTED WITH THIOETHER OR ESTER LINKAGES AT THE 2-ALPHA-POSITION
 
Creator DESAI, UR
TRIVEDI, GK
 
Subject steroids
synthesis
haptens
7-(3-oxocholest-4-en-2-alpha-yl)-5-oxa-4-oxoheptanoic acid
6-(3-oxocholest-4-en-2-alpha-yl)-4-thiahexanoate acid
spiro[4-cholestene-2,1'-cyclopropane]-3-one, radioimmunoassay
2-alpha-(2'-hydroxyethyl)cholest-4-en-3-one
2-beta-(2'-iodoethyl)-cholest-4-en-3-one
methyl 6-(3-oxocholest-4-en-2-alpha-yl)-4-thiahexanoate
 
Description Haptens with bridge at the 2-position have not yet been explored. Radioimmunoassays with antibodies directed against 2-alpha-alkyl bridged steroid haptens are expected to be highly specific due to greater topographical exposure and similarity in conformation to the native steroid. The 2-alpha-alkyl bridged haptens were synthesized by first adding a cyclopropane ring to 2-methylene-4-en-3-one. Selective opening of the three-membered ring with trimethyl silyl iodide and transformation of the iodo group gave a carbocyclic acid, the desired analog for conjugation with protein.
 
Publisher BUTTERWORTH-HEINEMANN
 
Date 2011-07-19T07:05:46Z
2011-12-26T12:51:03Z
2011-12-27T05:37:23Z
2011-07-19T07:05:46Z
2011-12-26T12:51:03Z
2011-12-27T05:37:23Z
1991
 
Type Article
 
Identifier STEROIDS, 56(4), 185-188
0039-128X
http://dx.doi.org/10.1016/0039-128X(91)90080-F
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5206
http://hdl.handle.net/10054/5206
 
Language en