Record Details

Partial molar volume fraction of solvent in binary (CO(2)-solvent) solution for solid solubility predictions

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Partial molar volume fraction of solvent in binary (CO(2)-solvent) solution for solid solubility predictions
 
Creator MUKHOPADHYAY, M
DALVI, SV
 
Subject carbon-dioxide
phase-behavior
antisolvent
mixtures
crystallization
expansion
system
partial molar volume fraction
solid solubility
solid-liquid equilibrium
solution phase-clustering
co(2) dissolution
antisolvent crystallization
 
Description Prediction of solid solute solubility in an organic solvent with dissolution of dense CO(2) as antisolvent is important for the design of antisolvent crystallization processes. A new model is proposed in this work to predict the mole fraction of a pure solid solute in a ternary (CO(2)-solvent-solid) system at solid-liquid equilibrium. This is based on the hypothesis that CO(2) molecules cluster around the solvent molecules at high values of CO, mole fraction. As a result the solvent molecules proportionately lose their affinity for the solid solute molecules. Accordingly the solid mole fraction in a solution is considered to be proportional to the partial molar volume fraction (PMVF) of the solvent in the binary (CO(2)-solvent) liquid solution or the solvent's contribution to the molar volume of the binary system. This model enables prediction of the liquid phase composition of the ternary system using only the binary information. The model has been validated, by predicting the solid solubility in various organic solvents, in good agreement with the corresponding experimental data from the literature, for several solids, such as beta-carotene, cholesterol, acetaminophen, as well as naphthalene, phenanthrene and salicylic acid. The performance of this model is found to be better than an earlier method, which uses the partial molar volume (PMV) of solvent in the CO(2)-solvent mixture. (C) 2003
 
Publisher ELSEVIER SCIENCE BV
 
Date 2011-07-26T01:49:20Z
2011-12-26T12:52:29Z
2011-12-27T05:38:13Z
2011-07-26T01:49:20Z
2011-12-26T12:52:29Z
2011-12-27T05:38:13Z
2004
 
Type Article
 
Identifier JOURNAL OF SUPERCRITICAL FLUIDS, 29(3), 221-230
0896-8446
http://dx.doi.org/10.1016/S0896-8446(03)00087-1
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6851
http://hdl.handle.net/10054/6851
 
Language en