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SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY OF (3,4-DIAMINOBENZOIC ACID)-HALOPLATINUM(II)/PALLADIUM(II)

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Title SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY OF (3,4-DIAMINOBENZOIC ACID)-HALOPLATINUM(II)/PALLADIUM(II)
 
Creator JAIN, N
SRIVASTAVA, TS
 
Subject platinum(ii) complexes
coordination-compounds
diethyldithiocarbamate
diamine
 
Description The synthesis of platinum compounds of the type [Pt(daba)X2] (where daba = 3,4-diaminobenzoic acid and X = Cl, Br, or I) and the analogous chloro and bromo compounds of Pd(II) has been carried out. These compounds have been characterized by molar conductance measurements, electronic absorption, infrared, H-1 NMR and X-ray photoelectron spectroscopy. The complexes are non-electrolytic in nature and have square planar geometry with two coordination positions occupied by two amino groups of 3,4-diaminobenzoic acid and remaining two positions occupied by halide ions. The sodium salts of the above compounds have been tested against P388 lymphocytic leukemia cells. [Pt(daba)Cl2] and Pt(daba)Br2] have I.D.50 values less than that of cisplatin and [Pt(daba)I2] has I.D.50 values comparable to that of cisplatin.
 
Publisher COUNCIL SCIENTIFIC INDUSTRIAL RESEARCH
 
Date 2011-07-21T03:05:04Z
2011-12-26T12:51:50Z
2011-12-27T05:38:31Z
2011-07-21T03:05:04Z
2011-12-26T12:51:50Z
2011-12-27T05:38:31Z
1992
 
Type Article
 
Identifier INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 31(2), 102-105
0376-4710
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5757
http://hdl.handle.net/10054/5757
 
Language en