Record Details

Vanadate and chromate reduction by saccharides and L-ascorbic acid: effect of the isolated V(IV) and Cr(III) products on DNA nicking, lipid peroxidation, cytotoxicity and on enzymatic and non-enzymatic antioxidants

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Vanadate and chromate reduction by saccharides and L-ascorbic acid: effect of the isolated V(IV) and Cr(III) products on DNA nicking, lipid peroxidation, cytotoxicity and on enzymatic and non-enzymatic antioxidants
 
Creator SREEDHARA, A
SUSA, N
RAO, CP
 
Subject cultured-mammalian-cells
one-electron reduction
chinese-hamster cells
in-vitro interaction
hydrogen-peroxide
oxovanadium(iv) complexes
hexavalent chromium
sodium chromate(vi)
potassium chromate
strand breaks
vanadate reduction
chromate reduction
saccharides
l-ascorbic acid
lipid peroxidation
cytotoxicity
dna nicking
 
Description Vanadate and chromate reduction in the presence of biocomponents like saccharides and L-ascorbic acid is demonstrated to generate V(IV) and Cr(III) species, respectively. The incipiently formed V(IV) and Cr(III) species are demonstrated to cause single strand and plasmid DNA nicking, lipid peroxidation and cytotoxicity in isolated rat hepatocytes. The V(IV) complexes depleted the levels of non-enzymatic antioxidants like L-ascorbic acid and glutathione and parallelly increased the levels of enzymatic antioxidants like glutathione reductase, glutathione S-transferase, glutathione peroxidase, superoxide dismutase and catalases. However, the Cr( Ill) species did not have any significant effect on the antioxidant enzymes. Thus the reducing and complexing abilities of biogenic ligands and the corresponding effects of the V(IV) and Cr(In) species generated from vanadate and chromate reduction, respectively, may lead to a better understanding of the toxic effects of the corresponding metal ions. (C) 1997 Elsevier Science S.A.
 
Publisher ELSEVIER SCIENCE SA
 
Date 2011-07-29T02:20:55Z
2011-12-26T12:47:42Z
2011-12-27T05:38:38Z
2011-07-29T02:20:55Z
2011-12-26T12:47:42Z
2011-12-27T05:38:38Z
1997
 
Type Article
 
Identifier INORGANICA CHIMICA ACTA, 263(1-2), 189-194
0020-1693
http://dx.doi.org/10.1016/S0020-1693(97)05609-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7551
http://hdl.handle.net/10054/7551
 
Language en