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Energetics of insertion of soluble proteins into membrane

DSpace at IIT Bombay

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Title Energetics of insertion of soluble proteins into membrane
 
Creator MATHUR, A
SETHI, A
JOGINI, V
BHARGAVA, Y
TEMBE, BL
LALA, AK
 
Subject diphtheria-toxin channels
bacillus-thuringiensis
transmembrane domain
transbilayer helices
refined structure
crystal-structure
delta-endotoxin
lipid-bilayers
resolution
binding
 
Description A number of soluble proteins that insert into membranes show a characteristic hairpin bent helix-helix pair, which is presumed to play an important role in insertion into the lipid membrane. However, little is known about the energetics of membrane insertion of such proteins. It is predicted that the spontaneous insertion of hydrophobic helical proteins into lipid bilayers is mainly driven by a hydrophobic free-energy and interaction of polar and charged side chains of protein with the solvent. With a consideration of hairpin bent a helix as an 'elliptical frustrum' we have demonstrated that insertion of such bent alpha-helices into the lipid bilayers is an outcome of various free energies like solvation, lipid perturbation, protein immobilization in lipid and packing energy. Different physical origins and different magnitudes of various free energies satisfy this model for insertion into the membranes.
 
Publisher CURRENT SCIENCE ASSN
 
Date 2011-07-21T05:57:55Z
2011-12-26T12:51:54Z
2011-12-27T05:38:41Z
2011-07-21T05:57:55Z
2011-12-26T12:51:54Z
2011-12-27T05:38:41Z
2004
 
Type Article
 
Identifier CURRENT SCIENCE, 87(2), 181-189
0011-3891
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5805
http://hdl.handle.net/10054/5805
 
Language en