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Nicotinamide and alpha-tocopherol combination partially protects t-butyl hydroperoxide-induced neurotoxicity: Implication for neurodegenerative disease

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Title Nicotinamide and alpha-tocopherol combination partially protects t-butyl hydroperoxide-induced neurotoxicity: Implication for neurodegenerative disease
 
Creator PARIHAR, MS
MANJULA, Y
BANO, S
HEMNANI, T
JAVERI, T
PRAKASH, P
 
Subject mitochondrial complex-i
parkinsons-disease
alzheimers-disease
oxidative damage
free-radicals
superoxide-dismutase
cytochrome-oxidase
coenzyme q(10)
brain
stress
 
Description In light of evidences of impaired energy metabolism and oxidative damage in neurodegenerative disorders, we have investigated the potential role of compounds which may improve the mitochondrial metabolism and can ameliorate the toxic effects of free radicals, and thus compensate for disease-related defects. Treatments with three doses of t-butyl hydroperoxide (t-BuOOH) resulted in increased lipid peroxidation in corpus striatum. The superoxide dismutase (SOD, EC 1.15.1.1) activity increased while reduced gluthathione content reclined. Supplementation with alpha-tocopherol and nicotinamide and their combination resulted in decline in LPO and showed the tendency towards normalization of SOD activity and GSH content. The results showed that supplementation of a combination of alpha-tocopherol and nicotinamide provides protection against t-BuOOH-induced neurotoxicity.
 
Publisher CURRENT SCIENCE ASSN
 
Date 2011-07-21T06:55:31Z
2011-12-26T12:51:55Z
2011-12-27T05:38:44Z
2011-07-21T06:55:31Z
2011-12-26T12:51:55Z
2011-12-27T05:38:44Z
1997
 
Type Article
 
Identifier CURRENT SCIENCE, 73(3), 290-293
0011-3891
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5819
http://hdl.handle.net/10054/5819
 
Language en