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Overexpression of G1/S cyclins and PCNA and their relationship to tyrosine phosphorylation and dephosphorylation during tumor promotion by metanil yellow and malachite green

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Title Overexpression of G1/S cyclins and PCNA and their relationship to tyrosine phosphorylation and dephosphorylation during tumor promotion by metanil yellow and malachite green
 
Creator SUNDARRAJAN, M
FERNANDIS, AZ
SUBRAHMANYAM, G
PRABHUDESAI, S
KRISHNAMURTHY, SC
RAO, KVK
 
Subject hepatic preneoplastic lesions
epidermal growth-factor
protein phosphatase-activity
rat hepatocyte cultures
n-nitrosodiethylamine
dna-synthesis
breast-cancer
kinase-activity
cell
liver
n-nitrosodiethylamine (den)
preneoplastic
metanil yellow (my)
malachite green (mg)
phenobarbitone (pb)
frank hepatocellular carcinoma
tyrosine phosphorylation
pcna
cyclin d1
cyclin e
 
Description Metanil yellow (MY) and Malachite green (MG) are textile dyes, which, despite the ban, occur unscrupulously as food colouring agents. Accordingly they constitute a serious public health hazard and are of sufficient environmental concern. We have earlier reported that both MY and MG have tumor promoting effects on the development of hepatic preneoplastic lesions induced by N-nitrosodielhylamine in rats. In order to understand the possible mechanism(s) by which metanil yellow (MY) and malachite green (MG) promotes liver tumor development, we have studied the tyrosine phosphorylation and protein phosphatases during tumor promotion. We have also investigated the possible overexpression of G1/S cyclins and PCNA during tumor promotion by MY and MG. The present investigation indicates that enhanced tyrosine phosphorylation is associated with no change in levers of tyrosine protein phosphatases. We have also observed an increase in the expression of PCNA and G1/S cyclins during tumor promotion. These factors collectively may contribute to the abnormal cell proliferation during tumor promotion by MY and MG. (C) 2000 Elsevier Science Ireland Ltd. .
 
Publisher ELSEVIER SCI IRELAND LTD
 
Date 2011-07-21T17:52:24Z
2011-12-26T12:52:06Z
2011-12-27T05:39:07Z
2011-07-21T17:52:24Z
2011-12-26T12:52:06Z
2011-12-27T05:39:07Z
2000
 
Type Article
 
Identifier TOXICOLOGY LETTERS, 116(1-2), 119-130
0378-4274
http://dx.doi.org/10.1016/S0378-4274(00)00216-2
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5941
http://hdl.handle.net/10054/5941
 
Language en