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The dnaSET: A novel device for single-molecule DNA sequencing

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Title The dnaSET: A novel device for single-molecule DNA sequencing
 
Creator MALI, P
LAL, RK
 
Subject electron transistor
fabrication
oxidation
affinity sensors
deoxyribonucleic acid (dna)
dna chip/sensors
dnaset
nanoeye
sequence analysis
single electron transistor (set)
single-molecule sensing
single-stranded dna (ssdna)
 
Description We present the principle of the dnaSET, a novel device for single-molecule sequence analysis of DNA strands. The central idea is to measure the variations in current through a single electron transistor (SET) as a target DNA molecule slithers through a nanoeye integrated between the SET's floating island and gate. We present a basic but illustrative simulation of the operation, and the results therefrom lead us to conclude that the dnaSET has a singlenucleotide resolution that enables it to read off the individual bases in a DNA strand. The versatility of this idea makes it suitable for incorporation in other bio-assay tools, and thus the dna/proteinSET promises to be a powerful direct sensing device for a wide range of applications.
 
Publisher IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
 
Date 2011-08-01T17:42:09Z
2011-12-26T12:53:27Z
2011-12-27T05:39:11Z
2011-08-01T17:42:09Z
2011-12-26T12:53:27Z
2011-12-27T05:39:11Z
2004
 
Type Article
 
Identifier IEEE TRANSACTIONS ON ELECTRON DEVICES, 51(12), 2004-2012
0018-9383
http://dx.doi.org/10.1109/TED.2004.839740
http://dspace.library.iitb.ac.in/xmlui/handle/10054/8501
http://hdl.handle.net/10054/8501
 
Language en