Record Details

Biodegradable hybrid polymeric membranes for ocular drug delivery

DSpace at IIT Bombay

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Title Biodegradable hybrid polymeric membranes for ocular drug delivery
 
Creator JAIN, D
CARVALHO, E
BANERJEE, R
 
Subject in-vivo evaluation
rheological characterization
systemic absorption
ophthalmic inserts
controlled-release
rabbit eyes
films
hydrogel
timolol
water
ocular inserts
ciprofloxacin hydrochloride
polyvinyl alcohol
sodium carboxymethylcellulose
ophthalmic drug delivery
 
Description Ophthalmic delivery systems such as ocular inserts are useful strategies to improve the ocular bioavailability of topically administered drugs. In the present study polyvinyl alcohol and sodium carboxymethylcellulose based ocular inserts were prepared by solution casting for sustained drug delivery of ciprofloxacin for treatment of topical infections. The polymers were esterified and the formation of ester bonds was confirmed by Fourier transform infrared spectroscopy. The inserts had a smooth structure with a surface roughness of 7.3 nm. Inserts were found to be wettable by simulated tear fluid with contact angle
 
Publisher ELSEVIER SCI LTD
 
Date 2011-07-21T21:31:33Z
2011-12-26T12:52:11Z
2011-12-27T05:39:13Z
2011-07-21T21:31:33Z
2011-12-26T12:52:11Z
2011-12-27T05:39:13Z
2010
 
Type Article
 
Identifier ACTA BIOMATERIALIA, 6(4), 1370-1379
1742-7061
http://dx.doi.org/10.1016/j.actbio.2009.11.001
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6000
http://hdl.handle.net/10054/6000
 
Language en